SJS/TEN is a very rare complication of medication use (estimated at 1–2/million each year for SJS, and 0.4–1.2/million each year for TEN). Using current definitions, it is nearly always caused by medications.
SJS/TEN is a rare, acute, serious, and potentially fatal skin reaction in which there are sheet-like skin and mucosal loss. Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are now believed to be variants of the same condition, distinct from erythema multiforme. What are Stevens–Johnson syndrome and toxic epidermal necrolysis?
